Sepsis Diagnosis

Documented Or Suspected Infection And “Some” Of The Following

 

• Hyperthermia (T > 38.3°C [100.94°F])

• Hypothermia (T < 36°C [96.8°F])

• Tachycardia (HR > 90/minute)

• Tachypnea (respiratory rate > 20/minute)

• Acutely altered mental status

• Hyperglycemia (glucose > 120 mg/dL) in the absence of diabetes

• Significant edema (> 20 mL/kg positive fluid balance in 24 hours)

 

Signs Of Inflammation

• Leukocytosis (WBC > 12,000/mm) or > 10% immature forms

• Leukopenia (WBC < 4000/mm)

• C-reactive protein > 2 standard deviations above normal

• Plasma procalcitonin > 2 standard deviations above normal

 

Hemodynamics

• Hypotension (SBP < 90 mmHg, MAP < 70 mmHg)

• SvO  > 70%

• Cardiac index > 3.5 L/min/m

 

Organ Dysfunction

• Arterial hypoxemia (PaO/FIO2 < 300)

• Acute oliguria (urine output < 0.5 mL/kg/hr for at least 2 hours

• Creatinine increase > 0.5 mg/dL

• Coagulopathy (INR > 1.5 or PTT > 60 seconds)

• Ileus

• Thrombocytopenia (platelet count < 100,000/mm)

• Hyperbilirubinemia (bilirubin > 4 mg/dL)

 

Tissue Perfusion Variables

• Lactate > 2 mmol/L

• Decreased capillary refill or mottling